Alastair Saunders

​What is your current research focused on?

My PhD project explores the regulators of metastatic cancer colonisation, with a particular focus on why cancers rarely metastasise to skeletal muscles. Under the supervision of Prof. Paul Gregorevic (unimelb) I have used recombinant AAVs to manipulate the skeletal muscle microenvironment in mouse models of metastatic breast cancer with Prof Robin Anderson (ONJCRI). Using animal models, we have developed models of spontaneous muscle metastasis. We are currently investigating the molecular mechanisms that deter metastatic seeding in muscle.

 

What is your study background and when did you decide you wanted to be a research scientist?

During high school my favourite subjects were always in science. However, I did not know what career path I wanted to follow so I did a Science degree at Melbourne Uni. At the end of my degree, I knew I was interested in physiology, but I was still unsure what career path I wanted to pursue, until I met with my now PhD supervisor about an honours project. I was so interested in the topic that I ended up doing a Master of Biomedical Science Project instead of honours. I enjoyed doing research so much that I then continued in the same lab for a PhD.

 

What attracted you to cancer research?

I enjoy learning about biology and how the body works, and research gives me the ability to be constantly learning new things. Unfortunately, I have also had a few members of my family that have been affected by metastatic cancers. This has inspired me to pursue a career in cancer research.

 

Why do you think research on metastases is important?

Metastatic cancers remain a significant clinical challenge and is unfortunately the reason that so many patients die with cancer. Whilst research efforts have uncovered many of the mechanisms behind metastatic colonisation and growth, there is still a lot that is unknown.

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What do you find exciting about your research work?

I like that there are so many different directions that your project can take you. My project has allowed me to learn lots of different techniques in the lab, so every day is a bit different. I also enjoy collaborating with other scientists. Sharing ideas with other scientists in the lab, and at meetings such as the OzMRS, has shaped my PhD project and given me new ideas and directions for my research.

 

What do you hope to achieve in your research career?

I hope to pursue a career in cancer research, particularly in metastasis biology. I hope that I can contribute in some way to the field and help to improve the lives of patients with metastatic disease.

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Any additional comments? 

​Thank you to the OzMRS committee for the opportunity to present a poster at the 2023 meeting. I look forward to the next OzMRS meeting!

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